ChatDRex: Conversational, no‑code AI for drug repurposing

Kari Jaaskelainen

27 Nov 2025 — 1 min read

Finding new uses for existing medicines can deliver treatments faster and cheaper—but today’s tools are fragmented and hard to use.

ChatDRex is a conversation-based, no‑code system that helps clinicians and researchers predict drug repurposing candidates simply by asking in natural language.

Built on the NeDRex biomedical knowledge graph to connect genes, diseases, and drugs.
Multi‑agent design: specialized agents handle data retrieval, network analysis, repurposing algorithms, and visualization.
In‑silico validation: functional coherence checks and literature mining to assess results.
Reasoning module keeps users in the loop and flags potential hallucinations.

Why it matters: ChatDRex lowers the barrier to advanced bioinformatics, enabling faster hypothesis generation and supporting personalized medicine and translational research.

Preprint: https://arxiv.org/abs/2511.21438v1

Authors: Simon Süwer, Kester Bagemihl, Sylvie Baier, Lucia Dicunta, Markus List, Jan Baumbach, Andreas Maier, Fernando M. Delgado‑Chaves

Paper: https://arxiv.org/abs/2511.21438v1

Register: https://www.AiFeta.com

#DrugRepurposing #AI #Bioinformatics #Healthcare #KnowledgeGraph #LLM #MultiAgent #NoCode

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