From Fluorescent Glow to Familiar H&E: An AI Bridge for Pathology

Kari Jaaskelainen

14 Jan 2026 — 1 min read

Pathologists read H&E-stained slides; researchers capture fluorescent “glow” images. This study shows how AI can translate between them so everyone sees the same story.

Using a CycleGAN (a type of image-to-image translation model), the method turns multi-channel fluorescence microscopy into convincing, H&E-like images—without needing perfectly paired training examples. It preserves cell and tissue shapes while adopting the familiar pink-and-purple palette.

No paired data: learns from separate sets of fluorescence and H&E images.
Structure first: maintains morphology that matters for interpretation.
Plug-in friendly: helps fit fluorescence data into H&E-based workflows and tools.

See fluorescence through a pathologist’s eyes—without changing the experiment.

Paper by Yanhua Zhao. Read more: https://arxiv.org/abs/2601.08776v1

Paper: https://arxiv.org/abs/2601.08776v1

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#AI #Pathology #Microscopy #DigitalPathology #MedicalImaging #DeepLearning #CycleGAN #HealthcareAI

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