MedBayes‑Lite: An AI for healthcare that knows when to say “I’m not sure”

MedBayes‑Lite: An AI for healthcare that knows when to say “I’m not sure”

AI can be impressively accurate in medicine—but dangerously overconfident when cases are ambiguous. MedBayes‑Lite offers a fix: a lightweight add‑on that helps clinical language models say how sure they are.

How it helps, without retraining:

  • Estimates what the model doesn’t know (epistemic uncertainty) using Monte Carlo dropout.
  • Downweights unreliable tokens with uncertainty‑aware attention.
  • Flags risky answers for human review, aligning decisions with clinical risk.

Plug‑in, not a rebuild: no new trainable layers and under 3% extra parameters.

On MedQA, PubMedQA, and MIMIC‑III, it improved calibration and trustworthiness—cutting overconfidence by 32–48%. In simulated clinical workflows, it could prevent up to 41% diagnostic errors by routing uncertain cases to clinicians.

Bottom line: a more cautious, transparent AI assistant designed for real‑world oversight—not a replacement for clinicians.

Paper: https://arxiv.org/abs/2511.16625v1

Paper: https://arxiv.org/abs/2511.16625v1

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